Since 2000, we’ve invested over $47 million in more than 105 companies.

Our diverse portfolio of invested companies are building the next generation of big solutions, from improving the way students learn to modifying the genes of illness. The common denominator: exceptional entrepreneurs on a clear, forceful path to value creation.

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appsFreedom

Our ready-to-use mobile apps for SAP give business users fast, secure access to enterprise systems from any mobile device. Launch fast, buy only what you need, scale easily.

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AQ BioMed

AQ BioMed is a medical device company commercializing next generation glaucoma drainage device to address the $3B glaucoma market. Based on over 20 years of research and development, the patented Oculieve™ drainage device is implanted in the eye by a MIGS (Minimally Invasive Glaucoma Surgery) to relieve over-pressurization caused by glaucoma.

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Avery Therapeutics, Inc.

Avery Therapeutics, Inc. is a pre-clinical stage company developing regenerative therapeutics. Avery’s lead product, MyCardia, is a tissue engineered graft for treatment of chronic heart failure, a disease affecting 24M people worldwide.

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Beacon Biomedical

Beacon will be providing healthcare providers with easy, accurate and affordable traditional laboratory & point-of-care (POC) blood-based tests they can use to screen their patients for the presence of undiagnosed colorectal cancer for less than $75. The added benefit of the POC version will be access to test results in under 10-minutes.

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Beem Biologics Inc.

Beem Biologics is a developer and manufacturer of sustainable, organic agricultural chemicals with a target ROI of 5X for the grower. The 1st generation of these products are sourced from guayule, a desert shrub, that is an all natural renewable resource.

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bioVidria

bioVidria, Inc. is focused on developing and manufacturing a wide variety of labware used in genetics research based on a novel and proprietary surface technology. This technology can be applied to microarrays, multi-well plates, and other labware critical to research conducted in both corporate and academic laboratories.

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BioVigilant

BioVigilant Systems invented instantaneous microbial detection technology to address environmental monitoring needs in pharmaceutical, biotechnology, healthcare, and environmental applications. BioVigilant’s IMD systems detect—instantaneously and in real time—particulate count, size, and biological status

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Bitsbox

Bitsbox teaches grade school kids to code. Our website provides the world’s easiest app programming environment, then we publish fun, monthly projects for homes and schools.

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Calimmune

Calimmune has assembled a world-class team of researchers, clinicians and translational experts in related fields of science and medicine to develop innovative cell-based therapies for HIV. The company formed around stem cell technology discovered in the labs of Nobel Laureate, Dr. David Baltimore (Caltech) and Dr. Irvin Chen (UCLA AIDS Institute) in early 2000.

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CampusLogic

CampusLogic is a student financial aid self-service company which is transforming the way colleges and universities exchange data and documents with their students through a secure, cloud-based self-service platform

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Cancer Prevention Pharmaceuticals

Cancer Prevention Pharmaceuticals, Inc. (CPP) is a biopharmaceutical company developing cancer prevention therapies that will effectively and safely reduce the risk of cancer for people with elevated risk. The Company is initially focused on Familial Adenomatous Polyposis (FAP) which is a precursor to colon cancer. CPP works collaboratively with the National Cancer Institute (NCI) and multiple academic partners

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Carb-BOOM

Carbboom Nutrition Inc. produces and markets sport nutrition products geared towards endurance athletes. We are committed to serving the athletes with the best ingredients and the best tasting products. All of our products do not contain anything artificial. Our premium fruit flavored gels are make with real fruits purees and concentrates.

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CellzDirect

Now part of the Invitrogen family, CellzDirect provides high-quality in vitro ADME cell products and contract laboratory and consulting services focused primarily on drug metabolism and transport. With CellzDirect’s support, scientists conduct research that accelerates the discovery of safe and effective drugs

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CircleIn

Think of CircleIn is an education-focused version of Slack. It enables student-to-student tutoring — learning and supporting through easy (but also safe/secure) sharing of knowledge/resources. Students participate in chat study groups for each course they take, video study sessions to get feedback or prepare for a test, and contribute to a growing searchable database where students share class notes, flashcards, websites or any content that provides assistance to the community. CircleIn is the place where students can get help anytime they need it and where they can study in groups together.

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ClearVoice

We are a simple platform that helps digital marketers more effectively create, manage, and market their content on the Internet.

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ClickIPO

The ClickIPO app allows everyday investors to discover, follow, share and even participate in public offerings using a supported brokerage account. Investors can use ClickIPO to invest in companies at the Initial Public Offering price (commission free), before the shares trade on a stock exchange.

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Codelucida

Codelucida is developing new disruptive error-correction technology for next-generation for storage and communications with initial focus on solid state drives (SSDs). The technology addresses a major need in the growing SSD market as SSDs face major issues in terms of reliability, speed, and power.

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Commerce Bank of Arizona/CBOA Financial

The last locally owned and operated bank serving small businesses in Southern Arizona.  CBOA provides loan and deposit services to small businesses in southern and central Arizona.

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Cyber Reconnaissance, Inc.

CYR3CON™, Inc. specializes in identifying cyber-threats in the earliest stages. We leverage both human analysts and advanced machine learning capabilities to search portions of the internet where malicious hackers organize, plan, purchase malware, sell exploits, and conduct other activities prior to conducting a cyber-attack.
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Desert Owl Games

Desert Owl Games produces the free-to-play PC game, Void Rim. By removing the subscription requirement that limits the competition, we are able to reach gamers more quickly and build lasting customer relationships through interactive communities and completed expansion content. Founded by the pioneers of microtransaction and free to play spaces in the US, Desert Owl Games not only created, but has a true understanding, of this market.

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Education Funding Parners

Education Funding Partners puts the power of Fortune 500 marketing resources to work for public education by linking carefully selected brands and forward-thinking school districts to build successful partnerships.

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EggCyte

EggCyte is a personal cloud technology company that provides consumers with a truly private user-friendly alternative to cloud services and social media for storing and sharing personal content

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eMoneyPool

eMoneyPool brings the age-old concept of money pools into the 21st century with an online platform to make the process easier, safer and more accessible.

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Endovantage

EndoVantage provides pre-treatment computer simulations of medical device implants. Clinicians now for the first time can design the optimal treatment strategy for each patient before surgery, thereby improving treatment quality and reducing cost.

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eVisit

eVisit® is a telemedicine software platform for medical practices and health systems. Our SaaS application (available via web browser and native mobile applications) allows physicians, nurse practitioners, and physician assistants to diagnose their patients remotely via high-resolution, 2-way video; and collect payment and electronically prescribe treatment to over 66,000 pharmacies nationwide.

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Gryphon Online Safety, Inc.

Gryphon is a simple to use cloud managed network protection service for homes and small businesses. For a reoccurring monthly fee, Gryphon will protect all the connected devices in the home or business from inappropriate content, viruses, ransomware, and unwanted intrusions. The software will automatically update to provide the latest protection for the network.

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GT Medical Technologies, Inc.

GT has developed an innovative approach to the treatment of brain tumors by combining a conformable collagen matrix with brachytherapy (radiation) seeds. The company’s first therapy, GammaTile™, was recently cleared by the FDA for use in the treatment of recurrent intracranial neoplasms and GT plans to launch the product in Q4 of 2018.  The product has the promise to revolutionize treatment for 175,000 patients/year in the US alone.

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HTG Molecular Diagnostics

HTG Molecular Diagnostics (HTG) was founded in 1997 with the mission to develop a universal molecular biology-based platform to improve the pharmaceutical drug discovery process. Since that time, HTG has expanded the utility of qNPA™ technology into the fields of gene expression profiling, Translational Medicine and Diagnostic applications and the measurement of miRNA.

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I.Me.Mine.

Our technology helps retailers to improve revenue and profitability by combining cognitive customer insights with a proprietary big data personalization engine, and an omni-channel delivery approach of individually relevant offers for shoppers. With automated machine learning, our affordable SaaS platform is built to deliver true competitive advantage.

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Instant Bioscan

Instant Bioscan uses its patented optical technology to offer a product that automatically detects microbes and particles in water in real time, unlike traditional methods of testing which require delayed test results and human interaction for the entire process.

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Iris PR Management

Iris is a cloud-based, Software-as-a-Service (SaaS) platform designed by PR pros, for PR pros. The platform manages media contacts and simplifies pitch management to improve client ROI.

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Late Living

Late Living is a platform for video marketing of retirement and senior communities.

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LawLytics, Inc

LawLytics is the leading website system for lawyers who want their marketing to work without wasting time or money. Unlike overpriced marketing companies, our system adapts as the law firm’s needs evolve, so our members don’t overpay. Unlike general website software, our system was built for lawyers, so our members don’t struggle or miss opportunities.

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Medical Referral Source

Medical Referral Source has developed an Internet referral system to streamline and improve patient care for any medical environment. Our easy-to-use web-based system increases revenues for our clients and creates cost-effective efficiencies by facilitating, managing and tracking healthcare referrals

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Medipacs

Headquartered in San Diego, California, Medipacs is focused on commercializing the first non-mechanical infusion pump based on a new, expandable polymer. The Medipacs novel polymer technology enables drug infusion pumps are that are wearable, programmable and disposable to allow for greater accuracy, patient comfort and convenience at a lower cost.

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MicroBlend Technologies

Welcome to MicroBlend Technologies. Our innovation is redefining paint – its quality, color, and dependability. We’re changing the way you think about paint. Our patented Automated Paint Machine™ (APM™) system dispenses on demand, at your location, a full-spectrum of interior and exterior latex paints and primers in multiple quality grades, in all sheen levels, in all colors and sizes.

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MSDx

MSDx, Inc. provides novel biomarker tools for studying disease processes. The company is focused on commercializing both Research Use Only and In Vitro Diagnostic blood test products that will be used in monitoring neurological, autoimmune, and inflammatory disorders.

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Naya Energy

Naya Energy has changed the optics of energy efficiency by offering an analytical energy management service to commercial and industrial businesses that provides visibility into exactly how they are using energy in order to help those companies reduce costs, prevent equipment failures, and increase operating margins. Naya Energy performs Energy Assessments that measures energy usage by connecting a company’s location to the Naya Energy Sensing Platform (Naya ESP™). Naya ESP increases both the granularity (down to the device-level) and the frequency (in real-time) with which organizations receive energy data making it actionable via alerts.

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NuvOx Pharma

NuvOx Pharma LLC is a Bio-Medical Nano-Technology company based in Tucson, Arizona. Forty years of industry experience drives NuvOx Pharma into exciting bio-technology advancements in therapeutic approaches to cancer, hemorrhagic shock, traumatic brain injury and stroke. The core technology of NuvOx is utilizing one particular perfluorocarbon, dodecafluoropentane (DDFP), which provides multiple advantages for respiratory gas transfer and can be applied to a host of therapeutic indications.

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Picmonic

Picmonic is an EdTech start-up reinventing the studying and memorizing habits of today’s students. The company offers a subscription-based service for its proprietary web application and audiovisual content.

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PlayAbility Toys

PlayAbility Toys is THE source of fun, unique toys that are developmentally appropriate for all young children and in particular children with special needs! The company specifically designs and markets toys that have many sensory features that incorporate auditory, tactile, visual and motor stimulation.

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Post.Bid.Ship

Post.Bid.Ship. operates an online marketplace for the commercial shipping and transportation industry. Shippers of freight post their transportation needs to postbidship.com and transportation providers submit competitive bids to haul the freight.

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PowerGrow Inc.

PowerGrow’s Renewable Powered Commercial Greenhouses enable farmers to mitigate all weather risk, grow 1,200% – 1,800% more produce per acre, use 95% less water, earn 2x – 3x greater profit.

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Prospectify, Inc.

Prospectify allows extremely targeted, automated and personalized outreach at scale to B2B salespeople making the still necessary cold-outreach that much warmer and less painful.

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Pure Chat

Pure Chat is a Live Chat Solution for Web Sites and Sales Professionals.

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RBar Energy

RBar is a delicious, better-for-you snack bar that’s made on proprietary equipment and with limited whole ingredients. This equipment allows us to make a snack with no processed binders, syrups or pastes meaning that our customers get a healthier and better tasting natural snack.

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Regenesis Biomedical

Regenesis Biomedical Inc. is a privately held medical technology company focused on developing and marketing noninvasive regenerative medicine products. Regenesis developed, patented, and now markets the Provant® Therapy System, indicated for the palliative treatment of post-operative pain and edema in superficial soft tissue.

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Reglagene

Cancer is the number two killer of Americans. It will soon pass heart disease as the leading cause of death worldwide. Conventional approaches to creating new cancer therapies often fail to deliver. At Reglagene, we give hope to cancer patients through the creation of new medicines that attack cancer’s weaknesses in ways that were once out of reach. We earn revenue by licensing our intellectual property to pharmaceutical partners, a $30B market. We are the ONLY company that harnesses Quadruplex Master Switch Technology to discover new medicines.

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Regulonix

Regulonix is an early-stage biotechnology company developing non-opioid therapeutics that relieve chronic pain. By indirectly targeting the well-established and genetically validated pain target NaV1.7 sodium channel and focusing on the signaling pathways that control channel activity, the Regulonix team has isolated compounds demonstrated in animal models to be non-addictive and more effective than morphine.

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REhnu

REhnu’s goal is to produce solar electricity at the lowest cost of any method, by combining the best of concentrating and photovoltaic technologies, and by using the most efficient strategies for every aspect of manufacture and installation.

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ReplyBuy

We enable businesses and customers to effortlessly complete instant mobile transactions using their cell phones, tablets and other mobile computing devices. ReplyBuy layers real-time buyer transactions into a widespread text messaging infrastructure that already serves text messages to over 211 million Americans every day (1.6B+ Users World Wide) and delivers over 7+ trillion messages in the U.S. annually.

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Ryver

Everyone spends up to 60% of their day using email, and most of that is spent forcing email to do things it was never designed for – Team Communication being the most prevalent. Ryver brings all of a team’s communication together in one place and can be accessed from all devices.

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SalutarisMD

Salutaris Medical Devices is a clinical-stage medical device company that was founded to develop an investigational ophthalmic treatment for Wet Age-related Macular Degeneration (Wet AMD). SalutarisMD’s technology is being engineered to deliver improved outcomes for Wet AMD.

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Sandstone Diagnostics

Sandstone aims to disrupt the $44B clinical diagnostics industry by providing connected wellness products that allow consumers to measure, monitor, and improve key health markers at home. Our lead product, Trak, is a consumer male fertility test kit and mobile app that allows couples to monitor and improve sperm quality from the comfort and privacy of home.

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Serious Integrated

Our hardware, software, and development tools enable medical/industrial OEMs to quickly and easily add iPhone-like graphic front panels to their product lines.

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Siamab Therapeutics

Siamab is developing therapeutic antibodies targeting glycan alterations present in the majority of solid tumors — including colon, lung, ovarian, breast, prostate, and pancreatic cancer. Cancer cells mutate the glycans present on the cell surface to enable tissue invasion and metastases. Targeting glycans with antibodies offers the potential to provide patients with significant benefits in reducing tumor burden by both killing tumor cells and blocking metastatic behavior.

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SimpleWAN

Office CyberSecurity Simply Automated – We are the automated equivalent to a multi-site security guard system for the Internet connection and network.

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Stimwave Technologies

Stimwave Technologies Inc is a privately-held medical device company engaged in the development, manufacturing, commercialization and marketing of wireless microsize injectable medical devices for neurology markets. Stimwave strives to improve people’s lives through utilizing wireless neurostimulation technology that enables low cost alternatives to complicated and expensive surgery, coupled with convenient and safe methods of use easily incorporated into everyday life.

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Stream Dx

Stream Dx has developed a patent pending point of care telemedicine urine flow data collection platform, with the goal to assist urologists and primary care physicians identify and treat the 16.5 million aging males in the U.S. suffering from Lower Urinary Tract Symptoms (LUTS) by providing them with efficient quantitative tools to individualize treatment plans, reduce costs and improve patient outcomes.
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StrongWatch

StrongWatch Corporation has pioneered and developed autonomous surveillance technology that provides clients with actionable information for high value asset protection. These solutions are targeted to meet: military challenges in surveillance and force protection; government needs for more effective prevention-oriented surveillance and security systems; and real-time commercial asset protection.

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SynCardia Systems

SynCardia Systems, Inc. is a private company formed in 2001 to commercialize the SynCardia temporary CardioWest™ Total Artificial Heart. Today, with more than 800 implants, the SynCardia Total Artificial Heart is the only FDA, Health Canada and CE approved Total Artificial Heart in the world.

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Tempronics

Based on research that started in Oak Ridge National Labs, our devices employ a physical phenomenon called “thermotunneling” that promises to convert heat to electricity more efficiently and affordably than any existing means. It will also provide cleaner and quieter cooling for a wide variety of applications.

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Tiltify

Tiltify creates technology to augment gaming tournaments and marathons to help players raise the maximum amount of money for their charity.

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TruTouch Technologies

We develop, manufacture and market versatile noninvasive alcohol testing systems for both existing and emerging markets. TruTouch’s patented, revolutionary technology is the fruit of a ten-year, $60-million investment in developing noninvasive, spectroscopy-based systems for biomedical applications

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Ugallery.com

We ventured to solve a fundamental problem in the art business – how can promising artists connect with people looking to buy reasonably priced, original artwork? Our solution was Ugallery.com, a virtual gallery that does that and more.

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Vartega Inc

Vartega Inc. is a recycler of advanced materials – specifically strong and lightweight carbon fiber – used in the aerospace, automotive, wind energy, and sporting goods industries. Vartega will produce low-cost recycled carbon fiber at a significant cost savings compared to virgin material.

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Vector Space Systems

Vector is a disruptive innovator that connects space startups with affordable and reliable space access. Vector has a BIG vision to reshape the multi-billion launch market and combines dedicated low-cost micro satellites launch (Vector Launch) AND software defined satellites (Galactic Sky) to dramatically increase access and speed to orbit.

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Veristride

Veristride’s instrumented insole wirelessly connects with a smartphone and cloud HIPAA-compliant servers to provide instant feedback and analysis about walking and balance, striving to revolutionize rehab.

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Western Alaska Copper and Gold

Western Alaska Copper and Gold is an exploration company with significant scale copper discoveries and a smaller scale gold discovery. Our mission is to advance the project through early economic analysis and put the property or the company up for sale.

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Whistle

Whistle is a customer service communication tool providing hotels the ability to communicate with guests through Mobile Messaging and SMS. A regular phone number with a hotel’s local area code is issued, and guests continue their regular messaging behaviors with the hotel. Virtual, consolidated cellphone for a business’ entire staff.